产品名称

LP-935509

产品货号

Axon 2638 CAS [1454555-29-3] MF C20H24N6O3MW 396.44 Purity: 99% Soluble in DMSO Description Potent, brain penetrant inhibitor of adapter protein-2 associated kinase 1 (AAK1; IC50 value 3.3 nM and 14 nM and 320 nM for the closely related BIKE and GAK enzymes, repsectively). LP-935509 is antinociceptive in multiple rat models of neuropathic pain, but not acute pain. The AAK1 inhibitor-induced antinociception and inhibition of spontaneous neural activity can be blocked by α2 adrenergic antagonists. KEYWORDS: LP-935509 | supplier | AAK1 inhibitor | LP935509 | CAS [1454555-29-3] | AAK | neuropathic pain | adapter protein-2 | AP-2 | antinociceptive | nociception | SNF1 family | endocytosis | clathrin | Notch

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

LP-935509

Based on 1 reference(s) in Google Scholar 9 10 1

Axon 2638

CAS [1454555-29-3]

MF C20H24N6O3
MW 396.44

Purity: 99%
Soluble in DMSO

LP-935509

Description

Potent, brain penetrant inhibitor of adapter protein-2 associated kinase 1 (AAK1; IC50 value 3.3 nM and 14 nM and 320 nM for the closely related BIKE and GAK enzymes, repsectively). LP-935509 is antinociceptive in multiple rat models of neuropathic pain, but not acute pain. The AAK1 inhibitor-induced antinociception and inhibition of spontaneous neural activity can be blocked by α2 adrenergic antagonists.

W Kostich et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.

Brain penetrant inhibitor of adapter protein-2 associated kinase 1 (AAK1)

Chemical name

isopropyl 4-(3-(2-methoxypyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate

Parent CAS No.

[1454555-29-3]

产品资料