产品名称

ZCZ 011

产品货号

Axon 2543 CAS [1998197-39-9] MF C21H18N2O2SMW 362.44 Purity: 99% Soluble in DMSO Description Brain penetrant cannabinoid CB1 receptor positive allosteric modulator (PAM) which augments the in vitro and in vivo pharmacological actions of the CB1 orthosteric agonists CP55940 (pEC50 value 6.90) and N-arachidonoylethanolamine (AEA) and reduces neuropathic pain in the mouse with no psychoactive effects. KEYWORDS: ZCZ 011 | supplier | PAM of CB1 | ZCZ011 | CAS [1998197-39-9] | Cannabinoids | CB1 | PAM | positive allosteric modulator | brain penetrant | neuropathic pain

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

ZCZ 011

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2543

CAS [1998197-39-9]

MF C21H18N2O2S
MW 362.44

Purity: 99%
Soluble in DMSO

ZCZ 011

Description

Brain penetrant cannabinoid CB1 receptor positive allosteric modulator (PAM) which augments the in vitro and in vivo pharmacological actions of the CB1 orthosteric agonists CP55940 (pEC50 value 6.90) and N-arachidonoylethanolamine (AEA) and reduces neuropathic pain in the mouse with no psychoactive effects.

BM Ignatowska-Jankowska et al. A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects. Neuropsychopharmacology. 2015 Dec;40(13):2948-59.

JL Poklis et al. HPLC-MS-MS Determination of ZCZ-011, A Novel Pharmacological Tool for Investigation of the Cannabinoid Receptor in Mouse Brain Using Clean Screen FASt™ Column Extraction. J Anal Toxicol. 2015 Jun;39(5):353-8.

Brain penetrant CB1 positive allosteric modulator (PAM)

Chemical name

6-methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1H-indole

Parent CAS No.

[1998197-39-9]

产品资料