产品名称

Cuspin-1

产品货号

Axon 2438 CAS [337932-29-3] MF C13H10BrNOMW 276.13 Purity: 99% Soluble in DMSO Description Small molecule upregulator of the Survival of Motor Neuron protein (SMN; EC50 value 18 μM in SMA patient fibroblast cells); a tool compound that revealed that increasing Ras signaling upregulates SMN protein levels by increased phosphorylation of Erk, an important member of the Ras-Raf-MEK signaling cascade. KEYWORDS: Cuspin 1 | Supplier | SMN upregulator | Axon Medchem | Axon 2438 | Cuspin1 | CAS [337932-29-3] | GTP | RAS | RAF | MEK | ERK | Activator | Enzymes | Survival of Motor Neuron Protein | SMN | SMA | fibroblasts | Spliceosome | RNP

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Cuspin-1

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2438

CAS [337932-29-3]

MF C13H10BrNO
MW 276.13

Purity: 99%
Soluble in DMSO

Cuspin-1

Description

Small molecule upregulator of the Survival of Motor Neuron protein (SMN; EC50 value 18 μM in SMA patient fibroblast cells); a tool compound that revealed that increasing Ras signaling upregulates SMN protein levels by increased phosphorylation of Erk, an important member of the Ras-Raf-MEK signaling cascade.

KEYWORDS: Cuspin 1 | Supplier | SMN upregulator | Axon Medchem | Axon 2438 | Cuspin1 | CAS [337932-29-3] | GTP | RAS | RAF | MEK | ERK | Activator | Enzymes | Survival of Motor Neuron Protein | SMN | SMA | fibroblasts | Spliceosome | RNP

R.R. Letso et al. Small molecule screen reveals regulation of survival motor neuron protein abundance by Ras proteins. ACS Chem Biol. 2013 May 17;8(5):914-22.

R.R. Letso. Investigating neurodegenerative diseases with small molecule modulators. Thesis, Columbia University, 2011

Upregulator of the Survival of Motor Neuron protein (SMN) by Ras signaling activation

Chemical name

(5-bromopyridin-3-yl)(p-tolyl)methanone

Parent CAS No.

[337932-29-3]

产品资料