产品名称

BIX 02188

产品货号

Axon 1808 CAS [334951-92-7] MF C26H26N4O2MW 426.51 Purity: 99% Soluble in DMSO Description Selective dual MEK5 kinase inhibitor, with IC50 values of 4.3, 810, 1800, and >6300 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively. References Certificates Categories Extra info RJ Tatake et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem. Biophys. Res. Comm. 2008, 377(1), 120–125. Y Obara and N Nakahata. The signaling pathway leading to extracellular signal-regulated kinase 5 (ERK5) activation via G-proteins and ERK5-dependent neurotrophic effects. Mol. Pharmacol. 2010, 77(1), 10-16. BA Drew, ME Burowa , BS Beckman. MEK5/ERK5 pathway: The first fifteen years. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2012, 1825 (1), 37-48. E. Razumovskaya et al. Inhibition of MEK5 by BIX02188 induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD. Biochem. Biophys. Res. Commun. 2011, 412, 307-312. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Stem Cell MAPK EC 2.7.12.2 ERK MEK MEK5 inhibitor; ERK5 inhibitor Chemical name (Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N-methyl-2-oxoindoline-6-carboxamide Parent CAS No. [334951-92-7] Order Size Unit Price Stock 5 mg €125.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

BIX 02188

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1808

CAS [334951-92-7]

MF C26H26N4O2
MW 426.51

Purity: 99%
Soluble in DMSO

BIX 02188

Description

Selective dual MEK5 kinase inhibitor, with IC50 values of 4.3, 810, 1800, and >6300 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.