产品名称

PXS 4728A - PXS 4728 HCl

产品货号

Axon 2583 CAS [1478364-68-9] MF C15H21FN2O2.HClMW 316.80 Purity: 98% Soluble in water and DMSO Description Potent and orally available inhibitor of VAP-1 (aka SSAO/AOC3; IC50 value 5 nM), inhibiting neutrophil rolling and tethering in the mouse cremaster model, and showing >500-fold selectivity for VAP-1/SSAO over all the related human amine oxidases. PXS 4728 diminishes lung inflammation in a variety of models indicating proof of concept for a novel therapeutic approach in respiratory diseases that are characterized by neutrophilic pattern of inflammation. PXS 4728 is in clinical trials for the treatment of cardiometabolic diseases like the liver-related disease Nonalcoholic Steatohepatitis (NASH). KEYWORDS: PXS 4728A | supplier | VAP-1 inhibitor | PXS 4728 HCl | PXS4728 | CAS [1478364-68-9] | [1478364-40-7] | Mono-amines | VAP | Inhibitor | SSAO | AOC3 | neutrophil | adhesion molecules | VAP-1/SSAO | lung inflammation | COPD | airway | respiratory | steatohepatitis | NASH | liver disease | Semicarbazide Sensitive Amine Oxidase

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

PXS 4728A - PXS 4728 HCl

Based on 17 reference(s) in Google Scholar 9 10 17

Axon 2583

CAS [1478364-68-9]

MF C15H21FN2O2.HCl
MW 316.80

Purity: 98%
Soluble in water and DMSO

PXS 4728A

Description

Potent and orally available inhibitor of VAP-1 (aka SSAO/AOC3; IC50 value 5 nM), inhibiting neutrophil rolling and tethering in the mouse cremaster model, and showing >500-fold selectivity for VAP-1/SSAO over all the related human amine oxidases. PXS 4728 diminishes lung inflammation in a variety of models indicating proof of concept for a novel therapeutic approach in respiratory diseases that are characterized by neutrophilic pattern of inflammation. PXS 4728 is in clinical trials for the treatment of cardiometabolic diseases like the liver-related disease Nonalcoholic Steatohepatitis (NASH).

M Wong et al. Semicarbazide-sensitive amine oxidase (SSAO) inhibition ameliorates kidney fibrosis in a unilateral ureteral obstruction murine model. Am J Physiol Renal Physiol. 2014 Oct 15;307(8):F908-16.

HC Schilter et al. Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration. Respir Res. 2015 Mar 20;16:42.

Cardiovascular Cell Signaling & Oncology Diabetes & Metabolism Immunology Pain & Inflammation VAP EC 1.4.3.21

Potent inhibitor of VAP-1/SSAO inhibiting neutrophil rolling and tethering

Chemical name

(E)-4-(2-(aminomethyl)-3-fluoroallyloxy)-N-tert-butylbenzamide hydrochloride

Parent CAS No.

[1478364-40-7]

产品资料