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产品名称 GSK 2256294A - GSK 2256294
产品货号 Axon 2220 CAS [1142090-23-0] MF C21H24F3N7OMW 447.46 Purity: 99% Optical purity: Optically pure (absolute stereochemistry) Soluble in DMSO Description GSK2256294A is a potent, reversible, tight binding inhibitor of isolated recombinant human sEH (IC50 value 27 pM), and displays potent inhibition against the rat (IC50 = 61 pM) and murine (IC50 = 189 pM) orthologs of sEH. GSK2256294A also displays potent cellular inhibition (IC50 = 0.66 nM) of sEH in a cell line transfected with the human sEH enzyme.The selectivity of the compound has been demonstrated by testing against a large panel of enzymes, receptors and ion channels, including the phosphatase activity of EPHX2. References Certificates Categories Extra info P.L. Podolin et al. In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor. Prostaglandins Other Lipid Mediat. 2013, 104-105, 25-31.   L.A. Morgan et al. Soluble epoxide hydrolase inhibition does not prevent cardiac remodeling and dysfunction after aortic constriction in rats and mice. J. Cardiovasc. Pharmacol. 2013, 61, 291-301.  Certificate of Analysis Material Safety Data Sheet Cardiovascular Cell Signaling & Oncology Diabetes & Metabolism Pain & Inflammation sEH NF-κB EC 3.3.2.10 Potent, reversible, tight binding inhibitor of recombinant human sEH Chemical name (1R,3S)-N-(4-cyano-2-(trifluoromethyl)benzyl)-3-(4-methyl-6-(methylamino)-1,3,5-triazin-2-ylamino)cyclohexanecarboxamide Parent CAS No. [1142090-23-0] Order Size Unit Price Stock 2 mg €125.00 In Stock
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产品品牌 axonmedchem
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GSK 2256294A - GSK 2256294

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2220

CAS [1142090-23-0]

MF C21H24F3N7O
MW 447.46

  • Purity: 99%
  • Optical purity: Optically pure (absolute stereochemistry)
  • Soluble in DMSO

GSK 2256294A

Description

GSK2256294A is a potent, reversible, tight binding inhibitor of isolated recombinant human sEH (IC50 value 27 pM), and displays potent inhibition against the rat (IC50 = 61 pM) and murine (IC50 = 189 pM) orthologs of sEH. GSK2256294A also displays potent cellular inhibition (IC50 = 0.66 nM) of sEH in a cell line transfected with the human sEH enzyme.The selectivity of the compound has been demonstrated by testing against a large panel of enzymes, receptors and ion channels, including the phosphatase activity of EPHX2.
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