产品名称

SPL-B - Spindlactone B

产品货号

Axon 2474 CAS [1465248-60-5] MF C27H22N2O5MW 454.47 Purity: 98% Soluble in 0.1N HCl(aq) and DMSO Description Orally active inhibitor of transforming acidic coiled-coil protein (TACC3) that selectively inhibits the nucleation of centrosome microtubules in ovarian cancer cells, without affecting spindle assembly in normal cells. SPL significantly inhibits mitosis in cancer cells and suppresses in vivo tumor growth. KEYWORDS: SPL-B | supplier | TACC3 inhibitor | Spindlactone B | SPLB | CAS [1465248-60-5] | microtubules | MTs | TACC | Inhibitor | proteins | mitotic spindle | assembly | mitosis | centrosomal | TOGp | Aurora A | coumarin | cell-cycle regulation | differentiation

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

SPL-B - Spindlactone B

Based on 6 reference(s) in Google Scholar 9 10 6

Axon 2474

CAS [1465248-60-5]

MF C27H22N2O5
MW 454.47

Purity: 98%
Soluble in 0.1N HCl(aq) and DMSO

SPL-B

Description

Orally active inhibitor of transforming acidic coiled-coil protein (TACC3) that selectively inhibits the nucleation of centrosome microtubules in ovarian cancer cells, without affecting spindle assembly in normal cells. SPL significantly inhibits mitosis in cancer cells and suppresses in vivo tumor growth.

KEYWORDS: SPL-B | supplier | TACC3 inhibitor | Spindlactone B | SPLB | CAS [1465248-60-5] | microtubules | MTs | TACC | Inhibitor | proteins | mitotic spindle | assembly | mitosis | centrosomal | TOGp | Aurora A | coumarin | cell-cycle regulation | differentiation

R. Yao et al. A small compound targeting TACC3 revealed its different spatiotemporal contributions for spindle assembly in cancer cells. Oncogene. 2014 Aug 14;33(33):4242-52.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Stem Cell TACC

Inhibitor of TACC3 that inhibits nucleation of centrosome microtubules

Chemical name

8'-((ethyl(pyridin-4-ylmethyl)amino)methyl)-7'-hydroxy-2H,2'H-3,4'-bichromene-2,2'-dione

Parent CAS No.

[1465248-60-5]

产品资料