产品名称

AZD 8797 - CX3CR1 antagonist 18a

产品货号

Axon 2255 CAS [911715-90-7] MF C19H25N5OS2MW 403.56 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Potent and selective antagonist of the Fractalkine receptor (FKN or CX3CR1; Ki value 3.9 nM) with a 720 fold selectivity over the CXCR2 receptor, a 246-fold selectivity versus hCCR1 and 187-fold versus hCCR2 and no significant antagonism of the CCR4, CCR5, CCR6, CXCR3, and CXCR5 receptors. AZD 8797 displayed adequate metabolic stability and solubility and high Caco-2 permeability. Notably, AZD 8797 exhibited a significant interaction (>50% activity at 10 μM) for the adenosine A1 receptor only, and the selectivity was later determined to be 33-fold. KEYWORDS:

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

AZD 8797 - CX3CR1 antagonist 18a

Based on 4 publications in PubMed 10 10 4

Axon 2255

CAS [911715-90-7]

MF C19H25N5OS2
MW 403.56

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

AZD 8797

Description

Potent and selective antagonist of the Fractalkine receptor (FKN or CX3CR1; Ki value 3.9 nM) with a 720 fold selectivity over the CXCR2 receptor, a 246-fold selectivity versus hCCR1 and 187-fold versus hCCR2 and no significant antagonism of the CCR4, CCR5, CCR6, CXCR3, and CXCR5 receptors.
AZD 8797 displayed adequate metabolic stability and solubility and high Caco-2 permeability.
Notably, AZD 8797 exhibited a significant interaction (>50% activity at 10 μM) for the adenosine A1 receptor only, and the selectivity was later determined to be 33-fold.