产品名称

YJC-10592

产品货号

Axon 2636 CAS [1226894-87-6] MF C27H31ClF3N5O3MW 566.01 Purity: 98% Optical purity: Optically pure Soluble in DMSO Description YJC-10592 is a CC chemokine receptor 2 (CCR2) antagonist (IC50 value 1.12 μM), which also showed excellent inhibitory activity in the calcium assay (IC50 value 1.7 nM), and good potency in the chemotaxis assay (IC50 value 23 nM). In rats, YJC-10592 showed dose-dependent pharmacokinetics and low F value due to slower elimination and incomplete absorption. KEYWORDS: YJC-10592 | supplier | CCR2 antagonist | YJC10592 | YJC 10592 | CAS [1226894-87-6] | Chemokine | Antagonist | Receptors | CCR2 | CCR 2

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

YJC-10592

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2636

CAS [1226894-87-6]

MF C27H31ClF3N5O3
MW 566.01

Purity: 98%
Optical purity: Optically pure
Soluble in DMSO

YJC-10592

Description

YJC-10592 is a CC chemokine receptor 2 (CCR2) antagonist (IC50 value 1.12 μM), which also showed excellent inhibitory activity in the calcium assay (IC50 value 1.7 nM), and good potency in the chemotaxis assay (IC50 value 23 nM). In rats, YJC-10592 showed dose-dependent pharmacokinetics and low F value due to slower elimination and incomplete absorption.

KEYWORDS: YJC-10592 | supplier | CCR2 antagonist | YJC10592 | YJC 10592 | CAS [1226894-87-6] | Chemokine | Antagonist | Receptors | CCR2 | CCR 2

JW Lim et al. Synthesis and biological evaluation of 3-aminopyrrolidine derivatives as CC chemokine receptor 2 antagonists. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2099-102.

ES Du et al. Pharmacokinetics of YJC-10592, a novel chemokine receptor 2 (CCR-2) antagonist, in rats. Arch Pharm Res. 2016 Jun;39(6):833-42.

CCR2 antagonist

Chemical name

(R)-N-(2-(1-(2-(4-(2-chlorobenzoyl)piperazin-1-yl)ethyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide

Parent CAS No.

[1226894-87-6]

产品资料