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产品名称 FIPI hydrochloride
产品货号 Axon 2281 CAS [N.A.] MF C23H24FN5O2.HClMW 457.93 Purity: 99% Soluble in DMSO Description Phospholipase D (PLD) inhibitor (IC50 values of 20-25 nM for both PLD1 and PLD2) that rapidly blocks in vivo phosphatidic acid (PA) production with subnanomolar potency. FIPI does inhibit PLD regulation of F-actin cytoskeleton reorganization, PIP2 availability, cell spreading, and chemotaxis, indicating potential utility for it as a therapeutic for autoimmunity and cancer metastasis. References Certificates Categories Extra info W. Su et al. 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol. Pharmacol. 2009, 75, 437-446.   L. Monovich et al. Optimization of halopemide for phospholipase D2 inhibition. Bioorg. Med. Chem. Lett. 2007, 17, 2310-2311. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Pain & Inflammation EC 3.1.4.4 PLD Phospholipase D (PLD) inhibitor that blocks phosphatidic acid (PA) production in vivo Chemical name 5-fluoro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-1H-indole-2-carboxamide hydrochloride Parent CAS No. [939055-18-2] Order Size Unit Price Stock 5 mg €100.00 In Stock
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FIPI hydrochloride

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2281

CAS [N.A.]

MF C23H24FN5O2.HCl
MW 457.93

  • Purity: 99%
  • Soluble in DMSO

FIPI hydrochloride

Description

Phospholipase D (PLD) inhibitor (IC50 values of 20-25 nM for both PLD1 and PLD2) that rapidly blocks in vivo phosphatidic acid (PA) production with subnanomolar potency. FIPI does inhibit PLD regulation of F-actin cytoskeleton reorganization, PIP2 availability, cell spreading, and chemotaxis, indicating potential utility for it as a therapeutic for autoimmunity and cancer metastasis.
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