| 产品名称 | GSK-LSD1 |
| 产品货号 | Axon 2375 CAS [N.A.] MF C14H20N2.2HClMW 289.24 Purity: 99% Optical purity: mixture of trans-diastereomers Soluble in water and DMSO Description Irreversible inhibitor of the KDM1 family histone demethylase LSD1 (IC50 value 16 nM). GSK-LSD1 is >1000 fold selective over closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B), induces gene expression changes in cancer cell lines (average EC50 <5 nM), and inhibits cancer cell line growth (average EC50 <5 nM). References Certificates Categories Extra info O. Munoz et al. Aryl- and heteroarylcyclopropylamine compounds as LSD1 inhibitors and their preparation. PCT Int. Appl. (2013), WO 2013057320 A1 20130425. D.P. Mould et al. Reversible Inhibitors of LSD1 as Therapeutic Agents in Acute Myeloid Leukemia: Clinical Significance and Progress to Date. Med Res Rev. 2014 Nov 24. J. McGrath et al. Targeting histone lysine methylation in cancer. Pharmacol Ther. 2015 Jan 9. pii: S0163-7258(15)00003-0. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Epigenetics Immunology EC 1.14.11 Histone demethylase Irreversible inhibitor of the KDM1 family histone demethylase LSD1 Chemical name rel-N-((1R,2S)-2-phenylcyclopropyl)piperidin-4-amine dihydrochloride Parent CAS No. [1431368-48-7] Order Size Unit Price Stock 10 mg €110.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
GSK-LSD1Axon 2375 CAS [N.A.] MF C14H20N2.2HCl
Description
Irreversible inhibitor of the KDM1 family histone demethylase LSD1 (IC50 value 16 nM). GSK-LSD1 is >1000 fold selective over closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B), induces gene expression changes in cancer cell lines (average EC50 <5 nM), and inhibits cancer cell line growth (average EC50 <5 nM).
Irreversible inhibitor of the KDM1 family histone demethylase LSD1
Chemical namerel-N-((1R,2S)-2-phenylcyclopropyl)piperidin-4-amine dihydrochloride Parent CAS No.[1431368-48-7] |
| 产品资料 |
