产品名称

KDM5 inhibitor compound 48

产品货号

Axon 2809 CAS [1628210-26-3] MF C17H20N6OMW 324.38 Purity: 99% Soluble in DMSO Description Potent, selective and orally bioavailable KDM5 inhibitor (IC50 value of 15.1 nM for KDM5A) with improved cell potency (EC50 value of 0.34 μM, H3K4Me3 level in PC9 cells). Chemical probe suitable for studying KDM5 biological functions in vivo. KEYWORDS: KDM5 inhibitor compound 48 | supplier | KDM5 inhibitor | CAS [1628210-26-3] | Histone demethylase | Inhibitor | Enzymes | Orally bioavailable | PC9

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

KDM5 inhibitor compound 48

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2809

CAS [1628210-26-3]

MF C17H20N6O
MW 324.38

Purity: 99%
Soluble in DMSO

KDM5 inhibitor compound 48

Description

Potent, selective and orally bioavailable KDM5 inhibitor (IC50 value of 15.1 nM for KDM5A) with improved cell potency (EC50 value of 0.34 μM, H3K4Me3 level in PC9 cells). Chemical probe suitable for studying KDM5 biological functions in vivo.

J Liang et al. Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies. Bioorg Med Chem Lett. 2016 Aug 15;26(16):4036-41.

Selective and orally bioavailable KDM5 inhibitor

Chemical name

5-(1-tert-Butyl-1H-pyrazol-4-yl)-6-isopropyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

Parent CAS No.

[1628210-26-3]

产品资料