AZ 20

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2345

CAS [1233339-22-4]

MF C21H24N4O3S
MW 412.51

Purity: 99%
Optical purity: Optically pure
Soluble in 0.1N HCl(aq) and DMSO

AZ 20

Description

Potent, orally active and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity (IC50 value 5 nM). AZ 20 potently inhibits the growth of LoVo colorectal adenocarcinoma tumor cells in vitro, and is a useful compound to explore ATR pharmacology in vivo.

K.M. Foote et al. Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy.... J. Med. Chem. 2013, 56, 2125-2138.

M.R. Finlay et al. Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family. Bioorg. Med. Chem. Lett. 2012, 22, 5352-5359.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology ATR p53-Tumor Suppression PI3K-Akt-mTOR DNA-damage Response EC 2.7.11.1

Potent, orally active and selective inhibitor of ATR protein kinase

Chemical name

(R)-4-(2-(1H-indol-4-yl)-6-(1-(methylsulfonyl)cyclopropyl)pyrimidin-4-yl)-3-methylmorpholine

Parent CAS No.

[1233339-22-4]

产品资料