产品名称

CPI 4203

产品货号

Axon 2622 CAS [1628214-07-2] MF C16H14N4OMW 278.31 Purity: 99% Soluble in DMSO Description Selective inhibitor of KDM5 demethylases, structurally related to CPI 455 (Axon 2573) but ~25-fold less potent (IC50 value 250 nM for inhibition of full length KDM5A). Control compound to be used in combination with CPI 455 (Axon 2573). KEYWORDS: CPI 4203 | supplier | KDM5 inhibitor | CPI4203 | CAS [1628214-07-2] | Histone demethylase | Inhibitor | H3K4 | KDM5A | lysine | methylation | drug tolerance | cancer | DTP | SET-domain | negative control | CPI455

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

CPI 4203

Based on 11 reference(s) in Google Scholar 10 10 11

Axon 2622

CAS [1628214-07-2]

MF C16H14N4O
MW 278.31

Purity: 99%
Soluble in DMSO

CPI 4203

Description

Selective inhibitor of KDM5 demethylases, structurally related to CPI 455 (Axon 2573) but ~25-fold less potent (IC50 value 250 nM for inhibition of full length KDM5A). Control compound to be used in combination with CPI 455 (Axon 2573).

KEYWORDS: CPI 4203 | supplier | KDM5 inhibitor | CPI4203 | CAS [1628214-07-2] | Histone demethylase | Inhibitor | H3K4 | KDM5A | lysine | methylation | drug tolerance | cancer | DTP | SET-domain | negative control | CPI455

M Vinogradova et al. An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat Chem Biol. 2016 Jul;12(7):531-8.

Cell Signaling & Oncology Epigenetics EC 1.14.11 Histone demethylase

Selective inhibitor of KDM5 demethylases (H3K4 specific)

Chemical name

6-ethyl-7-oxo-5-o-tolyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

Parent CAS No.

[1628214-07-2]

产品资料