产品名称

CPI 455

产品货号

Axon 2573 CAS [1628208-23-0] MF C16H14N4OMW 278.31 Purity: 99% Soluble in DMSO Description Selective inhibitor of KDM5 demethylases (IC50 value 10 nM for inhibition of full length KDM5A) that specifically alters H3K4 methylation in several cell contexts and reduces survival of drug-tolerant cancer cells. CPI-455 possesses the target specificity required for an in vitro tool compound for exploring KDM5-dependent disease biology, including drug tolerance. Note: CPI 455 can be used in combination with a less potent control compound, by the authors of the 2016 Nature publication referred to as CPI 4203 (Axon 2622). KEYWORDS: CPI 455 | supplier | KDM5 inhibitor | CPI455 | CAS [1628208-23-0] | Histone demethylase | Inhibitor | H3K4 | KDM5A | lysine | methylation | drug tolerance | cancer | DTP | SET-domain

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

CPI 455

Based on 11 reference(s) in Google Scholar 10 10 11

Axon 2573

CAS [1628208-23-0]

MF C16H14N4O
MW 278.31

Purity: 99%
Soluble in DMSO

CPI 455

Description

Selective inhibitor of KDM5 demethylases (IC50 value 10 nM for inhibition of full length KDM5A) that specifically alters H3K4 methylation in several cell contexts and reduces survival of drug-tolerant cancer cells. CPI-455 possesses the target specificity required for an in vitro tool compound for exploring KDM5-dependent disease biology, including drug tolerance.

Note: CPI 455 can be used in combination with a less potent control compound, by the authors of the 2016 Nature publication referred to as CPI 4203 (Axon 2622).

M Vinogradova et al. An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat Chem Biol. 2016 Jul;12(7):531-8.

Selective inhibitor of KDM5 demethylases (H3K4 specific)

Chemical name

6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

Parent CAS No.

[1628208-23-0]

产品资料