产品名称

BAY 1895344

产品货号

Axon 2918 CAS [1876467-74-1 ] MF C20H21N7OMW 375.43 Purity: 99% Optical purity: Optically pure Soluble in 0.1N HCl(aq) and DMSO Description BAY 1895344 is a potent, highly selective and orally available ATR inhibitor (IC50 value of 7 nM), which potently inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 value of 78 nM). BAY 1895344 exhibits strong in vivo anti-tumor efficacy in monotherapy in a variety of xenograft models of different indications that are characterized by DDR deficiencies, inducing stable disease in ovarian and colorectal cancer or even complete tumor remission in mantle cell lymphoma models. KEYWORDS: BAY 1895344 | supplier | ATR inhibitor | BAY1895344 | BAY-1895344 | CAS [1876467-74-1] | DNA-damage response | ATR | Inhibitor | Enzymes | Ovarian | Colorectal | Mantle cell lymphoma

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

BAY 1895344

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2918

CAS [1876467-74-1 ]

MF C20H21N7O
MW 375.43

Purity: 99%
Optical purity: Optically pure
Soluble in 0.1N HCl(aq) and DMSO

BAY 1895344

Description

BAY 1895344 is a potent, highly selective and orally available ATR inhibitor (IC50 value of 7 nM), which potently inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 value of 78 nM). BAY 1895344 exhibits strong in vivo anti-tumor efficacy in monotherapy in a variety of xenograft models of different indications that are characterized by DDR deficiencies, inducing stable disease in ovarian and colorectal cancer or even complete tumor remission in mantle cell lymphoma models.

AM Wengner et al. Abstract 836: ATR inhibitor BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride in preclinical tumor models. Proceedings: AACR Annual Meeting 2017; April 1-5, 2017.

UT Luecking et al. Abstract 983: Identification of potent, highly selective and orally available ATR inhibitor BAY 1895344 with favorable PK properties and promising efficacy in monotherapy and combination in preclinical tumor models. Proceedings: AACR Annual Meeting 2017; April 1-5, 2017.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology ATR p53-Tumor Suppression PI3K-Akt-mTOR DNA-damage Response EC 2.7.11.1

Potent, orally available and highly selective inhibitor of ATR protein kinase

Chemical name

(R)-3-Methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine

Parent CAS No.

[1876467-74-1]

产品资料