产品名称

Pregabalin - PD 144723

产品货号

Axon 1823 CAS [148553-50-8] MF C8H17NO2MW 159.23 Purity: 98% Optical purity: Optically pure Soluble in water Description An analogue of γ-amino butyric acid (GABA) but inactive at GABA receptors. Pregabalin binds to the α2δ protein, an auxiliary protein associated with voltage-gated calcium channels in the central nervous system. Pregabalin reduces the synaptic release of several neurotransmitters by binding to α2δ subunits, possibly accounting for its actions in vivo to reduce neuronal excitability and seizures. Antiepileptic and analgesic. References Certificates Categories Extra info CP Taylor et al. Pharmacology and mechanism of action of pregabalin: The calcium channel α2–δ (alpha2–delta) subunit as a target for antiepileptic drug discovery. Epilepsy Res. 2007, 73, 137–150. Y Zhang et al. Development and validation of a direct enantiomeric separation of pregabalin to support isolated perfused rat kidney studies. J. Chrom. B. 2008, 875, 148–153. Certificate of Analysis Material Safety Data Sheet Cardiovascular Cell Signaling & Oncology CNS Pain & Inflammation α2δ subunit Unclassified Reduces synaptic signaling by binding to α2δ subunits Chemical name (S)-3-(aminomethyl)-5-methylhexanoic acid Parent CAS No. [148553-50-8] Order Size Unit Price Stock 10 mg €85.00 In Stock

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产品概述

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Pregabalin - PD 144723

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 1823

CAS [148553-50-8]

MF C8H17NO2
MW 159.23

Purity: 98%
Optical purity: Optically pure
Soluble in water

Pregabalin

Description

An analogue of γ-amino butyric acid (GABA) but inactive at GABA receptors. Pregabalin binds to the α2δ protein, an auxiliary protein associated with voltage-gated calcium channels in the central nervous system. Pregabalin reduces the synaptic release of several neurotransmitters by binding to α2δ subunits, possibly accounting for its actions in vivo to reduce neuronal excitability and seizures. Antiepileptic and analgesic.

CP Taylor et al. Pharmacology and mechanism of action of pregabalin: The calcium channel α2–δ (alpha2–delta) subunit as a target for antiepileptic drug discovery. Epilepsy Res. 2007, 73, 137–150.

Y Zhang et al. Development and validation of a direct enantiomeric separation of pregabalin to support isolated perfused rat kidney studies. J. Chrom. B. 2008, 875, 148–153.

Reduces synaptic signaling by binding to α2δ subunits

Chemical name

(S)-3-(aminomethyl)-5-methylhexanoic acid

Parent CAS No.

[148553-50-8]

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