产品名称

BMS 345541

产品货号

Axon 1731 CAS [547757-23-3] MF C14H17N5.HClMW 291.78 Purity: 98% Soluble in water and DMSO Description A cell-permeable and highly selective IKB kinase (IKK) inhibitor, binds at allosteric site of the enzyme; blocks NF-kB-dependent transcription in mice; Displays ~10-fold greater selectivity at IKK-2 over IKK-1. KEYWORDS: BMS 345541 | supplier | IKK inhibitor | BMS345541 | BMS-345541 | CAS [547757-23-3] | [445430-58-0] | IκB | IKK | IKB kinase | NF-kB-dependent transcription | cell-permeable | allosteric | IKK-2 | IKK-1

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

BMS 345541

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 1731

CAS [547757-23-3]

MF C14H17N5.HCl
MW 291.78

Purity: 98%
Soluble in water and DMSO

BMS 345541

Description

A cell-permeable and highly selective IKB kinase (IKK) inhibitor, binds at allosteric site of the enzyme; blocks NF-kB-dependent transcription in mice; Displays ~10-fold greater selectivity at IKK-2 over IKK-1.

KEYWORDS: BMS 345541 | supplier | IKK inhibitor | BMS345541 | BMS-345541 | CAS [547757-23-3] | [445430-58-0] | IκB | IKK | IKB kinase | NF-kB-dependent transcription | cell-permeable | allosteric | IKK-2 | IKK-1

JR Burke et al. BMS-345541 is a highly-selective inhibitor of IkB kinase, binds at an Allosteric site of the enzyme, and blocks NF-kB-dependent transcription in mice. J. Biol. Chem. 2003, 278(3), 1450-1456.

J Yang et al. BMS-345541 Targets Inhibitor of κB Kinase and Induces Apoptosis in Melanoma: Involvement of Nuclear Factor κB and Mitochondria Pathways. Clin. Cancer Res. 2006, 12, 950.

Cell-permeable and selective IKB (IKK) inhibitor

Chemical name

N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine hydrochloride

Parent CAS No.

[445430-58-0]

产品资料