产品名称

Autophinib

产品货号

Axon 2748 CAS [1644443-47-9] MF C14H11ClN6O3MW 346.73 Purity: 99% Soluble in DMSO Description Autophinib targets the lipid kinase vacuolar protein sorting 34 (VPS34), which is a promising target for selective autophagy modulation (IC50 value of 0.019 µM). Autophinib inhibits autophagy induced by starvation or rapamycin with IC50 values of 0.04 µM and 0.09 µM, respectively. KEYWORDS: Autophinib | supplier | VPS34 inhibitor | CAS [1644443-47-9] | Phosphatidylinositol | PI3K | Inhibitor | Enzymes | Autophagy

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Autophinib

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2748

CAS [1644443-47-9]

MF C14H11ClN6O3
MW 346.73

Purity: 99%
Soluble in DMSO

Autophinib

Description

Autophinib targets the lipid kinase vacuolar protein sorting 34 (VPS34), which is a promising target for selective autophagy modulation (IC50 value of 0.019 µM). Autophinib inhibits autophagy induced by starvation or rapamycin with IC50 values of 0.04 µM and 0.09 µM, respectively.

L Robke et al. Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34. Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8153-8157.

PIK3C3/Vps34 inhibitor

Chemical name

6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)pyrimidin-4-amine

Parent CAS No.

[1644443-47-9]

产品资料