产品名称

RO 4929097

产品货号

Axon 2521 CAS [847925-91-1] MF C22H20F5N3O3MW 469.40 Purity: 98% Optical purity: Optically pure Soluble in DMSO Description Potent γ-secretase inhibitor (GSI; IC50 value 4 nM) targeting Notch signaling with in vivo efficacy in various tumor cells, showing >100-fold selectivity with respect to 75 other proteins of various types (receptors, ion channels, and enzymes). Treatment of HEK293 cells with RO4929097 caused a dose-dependent decrease in the amount of Aβ peptides secreted into the culture medium (EC50 value 14 nM), and a strong dose-dependent inhibition of Notch processing in a Notch cell-based reporter assay (EC50 value 5 nM). KEYWORDS: RO 4929097 | Supplier | γ-Secretase inhibitor | RO4929097 | CAS [847925-91-1] | Amyloids | γ Secretase | Inhibitor | GSI | Notch | signaling | Aβ peptides | tumor | melanoma | gamma Secretase

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

RO 4929097

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2521

CAS [847925-91-1]

MF C22H20F5N3O3
MW 469.40

Purity: 98%
Optical purity: Optically pure
Soluble in DMSO

RO 4929097

Description

Potent γ-secretase inhibitor (GSI; IC50 value 4 nM) targeting Notch signaling with in vivo efficacy in various tumor cells, showing >100-fold selectivity with respect to 75 other proteins of various types (receptors, ion channels, and enzymes). Treatment of HEK293 cells with RO4929097 caused a dose-dependent decrease in the amount of Aβ peptides secreted into the culture medium (EC50 value 14 nM), and a strong dose-dependent inhibition of Notch processing in a Notch cell-based reporter assay (EC50 value 5 nM).