产品名称

DBZ, γ-Secretase Inhibitor

产品货号

Axon 1488 CAS [209984-56-5] MF C26H23F2N3O3MW 463.48 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Very potent and cell-permeable inhibitor of γ-secretase (GSI); potently inhibits Notch processing (IC50 values to be 1.7 nM in SupT1 cells) KEYWORDS: γ-Secretase Inhibitor DBZ | supplier | gamma-secretase inhibitor | DBZ | CAS [209984-56-5] | Amyloids | GSI | Notch signaling | lineage | differentiation | ERK-1 | MAPK

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

DBZ, γ-Secretase Inhibitor

Based on 285 publications in PubMed 10 10 285

Axon 1488

CAS [209984-56-5]

MF C26H23F2N3O3
MW 463.48

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

DBZ, γ-Secretase Inhibitor

Description

Very potent and cell-permeable inhibitor of γ-secretase (GSI); potently inhibits Notch processing (IC50 values to be 1.7 nM in SupT1 cells)

KEYWORDS: γ-Secretase Inhibitor DBZ | supplier | gamma-secretase inhibitor | DBZ | CAS [209984-56-5] | Amyloids | GSI | Notch signaling | lineage | differentiation | ERK-1 | MAPK

J Milano et al. Modulation of Notch Processing by γ-Secretase Inhibitors Causes Intestinal Goblet Cell Metaplasia and Induction of Genes Known to Specify Gut Secretory Lineage Differentiation. Toxicol. Sci. 2004, 82(1), 341-358.

TV Arumugam et al. Gamma secretase–mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nature Medicine 2006, 12, 621-623.

T Aleksic and SM Feller. Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells. Cell Communication and Signaling 2008, 6, 8.

List of publications using DBZ (Axon 1488) purchased from Axon Medchem

Cell Signaling & Oncology CNS Stem Cell γ Secretase EC 3.4.23.46

γ-Secretase inhibitor (GSI)

Chemical name

(S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-propionamide

Parent CAS No.

[209984-56-5]

产品资料