产品名称

Isoquinolinediol, 1,5- - NSC 65585

产品货号

Axon 2537 CAS [5154-02-9] MF C9H7NO2MW 161.16 Purity: 100% Soluble in 0.1N NaOH(aq) and DMSO Description PARP1-specific inhibitor (IC50 value 0.39 - 1.00 μM) and neuroprotective agent, that leads to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene in mouse Ltk cells. Treatment of 1,5-Isoquinolinediol significantly blocked mitochondrial membrane potential loss and AIF (apoptosis inducing factor) and cytochrome c release from the mitochondria. 1,5-Isoquinolinediol did not suppress pristimerin-induced JNK activation. KEYWORDS: 1,5-Isoquinolinediol | supplier | PARP inhibitor |NSC65585 |NSC65585 | CAS [5154-02-9] |DNA-RNA | PARP1 | Inhibitor | DHIQ | DIQ | poly |ADP-ribose | SSB | single strand breaks | Ltk cells | mitochondrial membrane potential |AIF| apoptosis inducing factor | neuroprotetcive | JNK

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Isoquinolinediol, 1,5- - NSC 65585

Based on 240 reference(s) in Google Scholar 9 10 240

Axon 2537

CAS [5154-02-9]

MF C9H7NO2
MW 161.16

Purity: 100%
Soluble in 0.1N NaOH(aq) and DMSO

Isoquinolinediol, 1,5-

Description

PARP1-specific inhibitor (IC50 value 0.39 - 1.00 μM) and neuroprotective agent, that leads to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene in mouse Ltk cells. Treatment of 1,5-Isoquinolinediol significantly blocked mitochondrial membrane potential loss and AIF (apoptosis inducing factor) and cytochrome c release from the mitochondria. 1,5-Isoquinolinediol did not suppress pristimerin-induced JNK activation.

KEYWORDS: 1,5-Isoquinolinediol | supplier | PARP inhibitor |NSC65585 |NSC65585 | CAS [5154-02-9] |DNA-RNA | PARP1 | Inhibitor | DHIQ | DIQ | poly |ADP-ribose | SSB | single strand breaks | Ltk cells | mitochondrial membrane potential |AIF| apoptosis inducing factor | neuroprotetcive | JNK

A. Semionov et al. 1,5-isoquinolinediol increases the frequency of gene targeting by homologous recombination in mouse fibroblasts. Biochem Cell Biol. 2003 Feb;81(1):17-24.

J.Y. Byun et al. Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells. Mol Pharmacol. 2009 Oct;76(4):734-44.

P. Decker et al. An improved nonisotopic test to screen a large series of new inhibitor molecules of poly(ADP-ribose) polymerase activity for therapeutic applications. Clin Cancer Res. 1999 May;5(5):1169-72.

Cell Cycle Regulation Cell Signaling & Oncology Diabetes & Metabolism Epigenetics DNA-damage Response EC 2.4.2.30 PARP

PARP1 inhibitor and neuroprotective agent

Chemical name

5-hydroxyisoquinolin-1(2H)-one

Parent CAS No.

[5154-02-9]

产品资料