产品名称

GeA-69

产品货号

Axon 2885 CAS [2143475-98-1] MF C20H16N2OMW 300.35 Purity: 99% Soluble in DMSO Recently added

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

GeA-69

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2885

CAS [2143475-98-1]

MF C20H16N2O
MW 300.35

Purity: 99%
Soluble in DMSO

Recently added

GeA-69

Description

GeA-69 is a selective, allosteric and cell-active macrodomain inhibitor targeting macrodomain 2 of PARP14 (IC50 value of 0.71 µM). Moreover, GeA-69 engages PARP14 MD2 in intact cells and prevents its localisation to sites of DNA damage.

M Schuller et al. Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14. ACS Chem Biol. 2017 Nov 17;12(11):2866-2874.

M Moustakim et al. Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2. Bioorg Med Chem. 2018 Jul 15;26(11):2965-2972.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Epigenetics DNA-damage Response EC 2.4.2.30 PARP

Selective allosteric and cell-active PARP14 MD2 inhibitor

Chemical name

N-(2-(9H-Carbazol-1-yl)phenyl)acetamide

Parent CAS No.

[2143475-98-1]

产品资料