产品名称

AG 014699 - PF 01367338 | Rucaparib

产品货号

Axon 1529 CAS [459868-92-9] MF C19H18FN3O.H3O4PMW 421.36 Purity: 98% Soluble in water and DMSO Description A PARP 1 inhibitor with potential chemosensitizing, radiosensitizing and antineoplastic activities; selectively binds to PARP1 (Ki=1.4 nM) and inhibits PARP1-mediated DNA repair, thereby enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. AG-014699 is the phosphate salt of AG 014447 (CAS 283173-50-2) and has improved aqueous solubility References Certificates Categories Extra info HD Thomas et al. Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial. Mol. Cancer Ther. 2007, 6(3), 945-56. P Plummer et al. Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors. Clin Cancer Res. 2008, 14(23), 7917-23. M Ali et al. Vasoactivity of AG014699, a Clinically Active Small Molecule Inhibitor of Poly(ADP-ribose) Polymerase: a Contributory Factor to Chemopotentiation In vivo? Clin. Cancer Res. 2009, 15(19), 6106-6112. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology Epigenetics DNA-damage Response EC 2.4.2.30 PARP PARP1 inhibitor Chemical name 8-Fluoro-2-(4-methylaminomethyl-phenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one phosphate Parent CAS No. [283173-50-2] Order Size Unit Price Stock 2 mg €75.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

AG 014699 - PF 01367338 | Rucaparib

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 1529

CAS [459868-92-9]

MF C19H18FN3O.H3O4P
MW 421.36

Purity: 98%
Soluble in water and DMSO

AG 014699

Description

A PARP 1 inhibitor with potential chemosensitizing, radiosensitizing and antineoplastic activities; selectively binds to PARP1 (Ki=1.4 nM) and inhibits PARP1-mediated DNA repair, thereby enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. AG-014699 is the phosphate salt of AG 014447 (CAS 283173-50-2) and has improved aqueous solubility