产品名称

NQ301 - Compound 211

产品货号

Axon 2702 CAS [130089-98-4] MF C18H12ClNO3MW 325.75 Purity: 99% Soluble in DMSO Description NQ301 is an allosteric noncompetitive selective CD45 inhibitor (IC50 value 200 nM). Antithrombotic agent. KEYWORDS: NQ301 | supplier | CD45 inhibitor | Compound 211 | NQ-301 | NQ 301 | Compound211 | Compound-211 | CAS [130089-98-4] | Non Selective (Tyrosine Specific Phosphomonoesters) | PTPRC | Inhibitor | Enzymes | Antithrombotic | CD45

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

NQ301 - Compound 211

Based on 4 reference(s) in Google Scholar 8 10 4

Axon 2702

CAS [130089-98-4]

MF C18H12ClNO3
MW 325.75

Purity: 99%
Soluble in DMSO

NQ301

Description

NQ301 is an allosteric noncompetitive selective CD45 inhibitor (IC50 value 200 nM). Antithrombotic agent.

KEYWORDS: NQ301 | supplier | CD45 inhibitor | Compound 211 | NQ-301 | NQ 301 | Compound211 | Compound-211 | CAS [130089-98-4] | Non Selective (Tyrosine Specific Phosphomonoesters) | PTPRC | Inhibitor | Enzymes | Antithrombotic | CD45

WS Kang et al. Antiplatelet and antithrombotic activities of NQ301, 2-chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone. Biol Pharm Bull. 1999 Dec;22(12):1284-7.

YH Zhang et al. Antiplatelet effect of 2-chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone (NQ301): a possible mechanism through inhibition of intracellular Ca2+ mobilization. Biol Pharm Bull. 2001 Jun;24(6):618-22.

YR Jin et al. An antithrombotic agent, NQ301, inhibits thromboxane A2 receptor and synthase activity in rabbit platelets. Basic Clin Pharmacol Toxicol. 2005 Sep;97(3):162-7.

MD Perron et al. Allosteric noncompetitive small molecule selective inhibitors of CD45 tyrosine phosphatase suppress T-cell receptor signals and inflammation in vivo. Mol Pharmacol. 2014 Apr;85(4):553-63.

Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology Immunology Stem Cell JAK-STAT PTPRC EC 3.1.3.48

Selective allosteric inhibitor of CD45

Chemical name

2-(4-Acetylphenylamino)-3-chloronaphthalene-1,4-dione

Parent CAS No.

[130089-98-4]

产品资料