| 产品名称 | AGI 6780 |
| 产品货号 | Axon 2274 CAS [1432660-47-3] MF C21H18F3N3O3S2MW 481.51 Purity: 99% Soluble in DMSO Description Inhibitor of isocitrate dehydrogenases (IDH) selective for mutant IDH2. AGI 6780 potently and selectively inhibits the tumor-associated mutant IDH2/R140Q (EC50 value <20 nM for reduction of 2HG levels in cell lines) in an allosteric manner at the dimer interface, and induces differentiation of TF-1 erythroleukemia and primary human acute myelogenous leukemia cells in vitro. References Certificates Categories Extra info F. Wang et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013, 340, 622-626. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Diabetes & Metabolism Epigenetics EC 1.1.1.42 Stem Cell Differentiator IDH Potent and selective inhibitor of the tumor-associated mutant IDH2 (R140Q) Chemical name N-cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoromethyl)phenyl)ureido)benzenesulfonamide Parent CAS No. [1432660-47-3] Order Size Unit Price Stock 5 mg €90.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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AGI 6780Axon 2274 CAS [1432660-47-3] MF C21H18F3N3O3S2
Description
Inhibitor of isocitrate dehydrogenases (IDH) selective for mutant IDH2.
AGI 6780 potently and selectively inhibits the tumor-associated mutant IDH2/R140Q (EC50 value <20 nM for reduction of 2HG levels in cell lines) in an allosteric manner at the dimer interface, and induces differentiation of TF-1 erythroleukemia and primary human acute myelogenous leukemia cells in vitro.
Potent and selective inhibitor of the tumor-associated mutant IDH2 (R140Q)
Chemical nameN-cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoromethyl)phenyl)ureido)benzenesulfonamide Parent CAS No.[1432660-47-3] |
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