| 产品名称 | AG-120 - Ivosidenib |
| 产品货号 | Axon 2746 CAS [1448347-49-6] MF C28H22ClF3N6O3MW 582.96 Purity: 99% Optical purity: 99.9% e.e. Soluble in DMSO Description AG-120 (Ivosidenib) is an oral, selective, first-in-class, potent inhibitor of mutant IDH1. Treatment with AG-120 decreased intracellular 2-HG levels, inhibited growth factor independent proliferation and restored erythropoietin (EPO)-induced differentiation in TF-1 IDH1-R132H cells. Similarly, pharmacological inhibition of mutant IDH1 enzyme with AG-120 in primary human blast cells cultured ex vivo provided an effective way to lower intracellular 2-HG levels and induced myeloid differentiation. KEYWORDS: AG-120 | supplier | IDH1 inhibitor | Ivosidenib | AG120 | AG 120 | CAS [1448347-49-6] | Isocitrate | IDH | Inhibitor | Enzymes |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
AG-120 - IvosidenibAxon 2746 CAS [1448347-49-6] MF C28H22ClF3N6O3
DescriptionAG-120 (Ivosidenib) is an oral, selective, first-in-class, potent inhibitor of mutant IDH1. Treatment with AG-120 decreased intracellular 2-HG levels, inhibited growth factor independent proliferation and restored erythropoietin (EPO)-induced differentiation in TF-1 IDH1-R132H cells. Similarly, pharmacological inhibition of mutant IDH1 enzyme with AG-120 in primary human blast cells cultured ex vivo provided an effective way to lower intracellular 2-HG levels and induced myeloid differentiation. KEYWORDS: AG-120 | supplier | IDH1 inhibitor | Ivosidenib | AG120 | AG 120 | CAS [1448347-49-6] | Isocitrate | IDH | Inhibitor | Enzymes
IDH1 mutant enzyme inhibitor
Chemical name(S)-N-((S)-1-(2-chlorophenyl)-2-(3,3-difluorocyclobutylamino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide Parent CAS No.[1448347-49-6] |
| 产品资料 |
