产品名称

Alda 1

产品货号

Axon 2551 CAS [349438-38-6] MF C15H11Cl2NO3MW 324.16 Purity: 99% Soluble in DMSO Description Small molecule activator of ALDH2 (EC50 value ca 6 μM for ALDH2 mediated acetaldehyde metabolism) with the ability to activate wild-type ALDH2 and restore near-wild-type activity to ALDH2*2. When administered to rats before an ischemic event, Alda 1 reduced infarct size by 60%, most likely through its inhibitory effect on the formation of cytotoxic aldehydes. Alda-1 was effective in protecting against rotenone-induced apoptotic cell death in both SH-SY5Y cells and primary cultured substantia nigra (SN) dopaminergic neurons, and significantly reduced rotenone- or MPTP-induced death of SN tyrosine hydroxylase (TH)-positive dopaminergic neurons. KEYWORDS: Alda 1 | supplier | ALDH2 activator | Alda1 | CAS [349438-38-6] | Alcohol | ALDH | Activator | agonist | ALDH2*2 | dehydrogenase | alcoholism | ischemia | chaperone | neuroprotective | dopamine neurons | rotenone | MPTP | substantia nigra

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Alda 1

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2551

CAS [349438-38-6]

MF C15H11Cl2NO3
MW 324.16

Purity: 99%
Soluble in DMSO

Alda 1

Description

Small molecule activator of ALDH2 (EC50 value ca 6 μM for ALDH2 mediated acetaldehyde metabolism) with the ability to activate wild-type ALDH2 and restore near-wild-type activity to ALDH2*2. When administered to rats before an ischemic event, Alda 1 reduced infarct size by 60%, most likely through its inhibitory effect on the formation of cytotoxic aldehydes. Alda-1 was effective in protecting against rotenone-induced apoptotic cell death in both SH-SY5Y cells and primary cultured substantia nigra (SN) dopaminergic neurons, and significantly reduced rotenone- or MPTP-induced death of SN tyrosine hydroxylase (TH)-positive dopaminergic neurons.

CH Chen et al. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science. 2008 Sep 12;321(5895):1493-5.

CH Chen et al. Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3074-9.

Small molecule activator of ALDH2

Chemical name

N-(benzo[d][1,3]dioxol-5-ylmethyl)-2,6-dichlorobenzamide

Parent CAS No.

[349438-38-6]

产品资料