产品名称

NU 1025

产品货号

Axon 1370 CAS [90417-38-2] MF C9H8N2O2MW 176.17 Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description Potent inhibitor of poly(ADP-ribose) polymerase (PARP); reported to have neuroprotective effects References Certificates Categories Extra info R Kaundal et al. Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation. Life Sciences 2006, 79(24), 2293-302. KJ Bowman et al. Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. Br. J. Cancer. 1998, 78 1269. CA Delaney et al. Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin. Cancer Res. 2000, 6, 2860. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology Epigenetics DNA-damage Response EC 2.4.2.30 PARP PARP inhibitor Chemical name 8-Hydroxy-2-methyl-3H-quinazolin-4-one Parent CAS No. [90417-38-2] Order Size Unit Price Stock 10 mg €80.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

NU 1025

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1370

CAS [90417-38-2]

MF C9H8N2O2
MW 176.17

Purity: 99%
Soluble in 0.1N NaOH(aq) and DMSO

NU 1025

Description

Potent inhibitor of poly(ADP-ribose) polymerase (PARP); reported to have neuroprotective effects

R Kaundal et al. Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation. Life Sciences 2006, 79(24), 2293-302.

KJ Bowman et al. Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. Br. J. Cancer. 1998, 78 1269.

CA Delaney et al. Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin. Cancer Res. 2000, 6, 2860.

PARP inhibitor

Chemical name

8-Hydroxy-2-methyl-3H-quinazolin-4-one

Parent CAS No.

[90417-38-2]

产品资料