PS 48

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 1659

CAS [1180676-32-7]

MF C17H15ClO2
MW 286.75

Purity: 99%
Soluble in DMSO and Ethanol

PS 48

Description

Allosteric activator of phosphoinositide-dependent protein kinase 1 (PDPK1 or PDK1). PS 48 has a Z-configuration in comparison with its inactive E-isomer PS 47 (Axon 1664)

A Stroba et al. 3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding (...). J. Med. Chem. 2009, 52(15), 4683-93.

V Hindie et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nature Chem. Biol. 2009, 5, 758-764.

Allosteric activator of phosphoinositide-dependent protein kinase 1 (PDPK1)

Chemical name

(Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid

Parent CAS No.

[1180676-32-7]

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