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产品名称 CP 346086
产品货号 Axon 2216 CAS [186390-48-7] MF C26H22F3N5OMW 477.48 Purity: 99% Soluble in DMSO Description Potent microsomal triglyceride transfer protein (MTP, MTTP) inhibitor that inhibits both human and rodent MTP activity (IC50 value 2.0 nM). After a 2 week treatment CP 346086 reduced total and LDL cholesterol and triglycerides by 47%, 72%, and 75%, relative to either individual baselines or placebo, with little change in HDL cholesterol. More potent in MTP inhibition than SLX 4090 and Lomitapide (Juxtapid; IC50 value 8 nM and 5-7 nM respectively). References Certificates Categories Extra info C.E. Chandler et al. CP-346086: an MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humans. J. Lipid. Res. 2003, 44, 1887-1901.    E. Kim et al. A small-molecule inhibitor of enterocytic microsomal triglyceride transfer protein, SLx-4090: biochemical, pharmacodynamic, pharmacokinetic, and safety profile. J. Pharmacol. Exp. Ther. 2011, 337, 775-785.  Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Diabetes & Metabolism MTP Pfizer Licensed Products Potent microsomal triglyceride transfer protein (MTP) inhibitor Chemical name N-(2-((1H-1,2,4-triazol-5-yl)methyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-4'-(trifluoromethyl)biphenyl-2-carboxamide Source information Pfizer compound; Sold for research purposes under agreement from Pfizer Inc. Parent CAS No. [186390-48-7] Order Size Unit Price Stock 10 mg €125.00 In Stock
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CP 346086

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2216

CAS [186390-48-7]

MF C26H22F3N5O
MW 477.48

  • Purity: 99%
  • Soluble in DMSO

CP 346086

Description

Potent microsomal triglyceride transfer protein (MTP, MTTP) inhibitor that inhibits both human and rodent MTP activity (IC50 value 2.0 nM). After a 2 week treatment CP 346086 reduced total and LDL cholesterol and triglycerides by 47%, 72%, and 75%, relative to either individual baselines or placebo, with little change in HDL cholesterol. More potent in MTP inhibition than SLX 4090 and Lomitapide (Juxtapid; IC50 value 8 nM and 5-7 nM respectively).
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