产品名称

Evacetrapib - LY 2484595

产品货号

Axon 2286 CAS [1186486-62-3] MF C31H36F6N6O2MW 638.65 Purity: 98% Optical purity: Optically pure Soluble in DMSO Description Potent, and selective inhibitor of cholesteryl ester transfer protein (CETP; IC 50 value 5.5 nM and 26 nM in human recombinant and plasme CETP assays, respectively) that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure. References Certificates Categories Extra info G. Cao et al. Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure. J. Lipid Res. 2011, 52, 2169-2176. D.G. Johns et al. On- and off-target pharmacology of torcetrapib: current understanding and implications for the structure activity relationships (SAR), discovery and development of CETP inhibitors. Drugs. 2012, 72, 491-507. N.B. Mantlo et al. Update on the discovery and development of cholesteryl ester transfer protein inhibitors for reducing residual cardiovascular risk. J. Med. Chem. 2014, 57, 1-17. Certificate of Analysis Material Safety Data Sheet Cardiovascular Cell Signaling & Oncology Diabetes & Metabolism CETP Potent, and selective inhibitor of CETP Chemical name trans-(1S,4r)-4-(((S)-5-((3,5-bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methyl)cyclohexanecarboxylic acid Parent CAS No. [1186486-62-3] Order Size Unit Price Stock 5 mg €125.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Evacetrapib - LY 2484595

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2286

CAS [1186486-62-3]

MF C31H36F6N6O2
MW 638.65

Purity: 98%
Optical purity: Optically pure
Soluble in DMSO

Evacetrapib

Description

Potent, and selective inhibitor of cholesteryl ester transfer protein (CETP; IC 50 value 5.5 nM and 26 nM in human recombinant and plasme CETP assays, respectively) that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure.

G. Cao et al. Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure. J. Lipid Res. 2011, 52, 2169-2176.

D.G. Johns et al. On- and off-target pharmacology of torcetrapib: current understanding and implications for the structure activity relationships (SAR), discovery and development of CETP inhibitors. Drugs. 2012, 72, 491-507.

N.B. Mantlo et al. Update on the discovery and development of cholesteryl ester transfer protein inhibitors for reducing residual cardiovascular risk. J. Med. Chem. 2014, 57, 1-17.

Potent, and selective inhibitor of CETP

Chemical name

trans-(1S,4r)-4-(((S)-5-((3,5-bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methyl)cyclohexanecarboxylic acid

Parent CAS No.

[1186486-62-3]

产品资料