产品名称

URB602

产品货号

Axon 2696 CAS [565460-15-3] MF C19H21NO2MW 295.38 Purity: 99% Soluble in DMSO Description Non-competitive inhibitor of MAGL (monoacylglycerol lipase; IC50 values 25 μM and 17 μM for inhibition of hydrolysis of 2-oleoylglycerol (2-OG) and anandamide (AEA), respectively), lacking affinity for FAAH, diacylglycerol lipase or COX-2. URB602 blocks 2-AG hydrolysis in rat brain slices and enhances non-opioid stress-induced analgesia. Furthermore, URB602 reduced xenograft tumor volume, this effect being associated to down-regulation of VEGF and FGF-2, reduction in the number of vessels and down-regulation of cyclin D1. KEYWORDS: URB602 | supplier | MAGL inhibitor | URB 602 | URB-602 | CAS [565460-15-3] | 2-arachidonoyl glycerol (2-AG) | MAGL | Inhibitor | Enzymes

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

URB602

Based on 42 publications in PubMed 10 10 42

Axon 2696

CAS [565460-15-3]

MF C19H21NO2
MW 295.38

Purity: 99%
Soluble in DMSO

URB602

Description

Non-competitive inhibitor of MAGL (monoacylglycerol lipase; IC50 values 25 μM and 17 μM for inhibition of hydrolysis of 2-oleoylglycerol (2-OG) and anandamide (AEA), respectively), lacking affinity for FAAH, diacylglycerol lipase or COX-2. URB602 blocks 2-AG hydrolysis in rat brain slices and enhances non-opioid stress-induced analgesia. Furthermore, URB602 reduced xenograft tumor volume, this effect being associated to down-regulation of VEGF and FGF-2, reduction in the number of vessels and down-regulation of cyclin D1.