| 产品名称 | IWP L6 |
| 产品货号 | Axon 2212 CAS [1427782-89-5] MF C25H20N4O2S2MW 472.58 Purity: 99% Soluble in DMSO Description Highly potent porcupine inhibitor (Porcn; EC50 value 0.5 nM), a membrane-bound O-acyltransferase (MBOAT); Wnt signaling inhibitor; 60-times more potent than IWP-2.IWP-L6 effectively inhibits posterior axis formation and resected tailfin regeneration in juvenile zebrafish at low micromolar concentrations. IWP L6 specifically and reversibly blocks Wnt signaling and Wnt mediated branching morphogenesis in cultured mouse embryonic kidneys. Stable in human plasma over 24 h. References Certificates Categories Extra info X. Wang et al. The development of highly potent inhibitors for porcupine. J. Med. Chem. 2013, 56, 2700-2704. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Stem Cell Porcupine Wnt-β-Catenin EC 2.3.1 Highly potent porcupine (Porcn) inhibitor Chemical name 2-(4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-ylthio)-N-(5-phenylpyridin-2-yl)acetamide Parent CAS No. [1427782-89-5] Order Size Unit Price Stock 10 mg €125.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
IWP L6Axon 2212 CAS [1427782-89-5] MF C25H20N4O2S2
Description
Highly potent porcupine inhibitor (Porcn; EC50 value 0.5 nM), a membrane-bound O-acyltransferase (MBOAT); Wnt signaling inhibitor; 60-times more potent than IWP-2.IWP-L6 effectively inhibits posterior axis formation and resected tailfin regeneration in juvenile zebrafish at low micromolar concentrations. IWP L6 specifically and reversibly blocks Wnt signaling and Wnt mediated branching morphogenesis in cultured mouse embryonic kidneys. Stable in human plasma over 24 h.
Highly potent porcupine (Porcn) inhibitor
Chemical name2-(4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-ylthio)-N-(5-phenylpyridin-2-yl)acetamide Parent CAS No.[1427782-89-5] |
| 产品资料 |
