产品名称

IWR-1-endo - IWR-1 | endo-IWR-1

产品货号

Axon 2510 CAS [1127442-82-3] MF C25H19N3O3MW 409.44 Purity: 99% Soluble in DMSO Description Small-molecule inhibitor of the Wnt/β-catenin pathway (IC50 value 0.18 μM), strongly inhibiting TNKS1 and TNKS2 in biochemical assays, and targeting the acyltransferase Porcupine (Porcn) without inducing Porcn destruction or mislocalization. IWR-1-endo significantly stabilized endogenous TNKS1, TNKS2 and axin 2 by inhibition of auto-PARsylation of TNKS in vivo and independent of the PARsylation activity of PARP1/2. Furthermore, IWR-1 increased expression of genes commonly expressed in cardiac mesoderm/progenitor cell and significantly improved cardiac differentiation when introduced after the application of BMP-4. KEYWORDS: IWR-1-endo | Supplier | Wnt/TNKS inhibitor | IWR-1 | IWR1 | CAS [1127442-82-3] | DNA-RNA | TNKS1 | TNKS2 | Tankyrase | Inhibitor | catenin | parp | parsylation | axin | cardiac | differentiation | Porcupine | Porcn

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

IWR-1-endo - IWR-1 | endo-IWR-1

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2510

CAS [1127442-82-3]

MF C25H19N3O3
MW 409.44

Purity: 99%
Soluble in DMSO

IWR-1-endo

Description

Small-molecule inhibitor of the Wnt/β-catenin pathway (IC50 value 0.18 μM), strongly inhibiting TNKS1 and TNKS2 in biochemical assays, and targeting the acyltransferase Porcupine (Porcn) without inducing Porcn destruction or mislocalization. IWR-1-endo significantly stabilized endogenous TNKS1, TNKS2 and axin 2 by inhibition of auto-PARsylation of TNKS in vivo and independent of the PARsylation activity of PARP1/2. Furthermore, IWR-1 increased expression of genes commonly expressed in cardiac mesoderm/progenitor cell and significantly improved cardiac differentiation when introduced after the application of BMP-4.