产品名称

JK184

产品货号

Axon 2654 CAS [315703-52-7] MF C19H18N4OSMW 350.44 Purity: 100% Soluble in DMSO and Ethanol Description Antagonist of Hedgehog (Hh) signaling (IC50 value of 30 nM for inhibition of Gli-dependent transcriptional activity) and a potent inhibitor of microtubule assembly that exhibits good antiproliferative activity both in vitro and in vivo. JK184 appears to act by inhibition of Adh7 (Kd value 210 nM in a assay for enzymatic oxidation of retinol). KEYWORDS: JK184 | supplier | Hedgehog inhibitor | JK-184 | CAS [315703-52-7] | [466638-53-9] | Hedgehog | ADH | Antagonist | Hh | Smoothened | Smo | Patched | Ptch1 | Ptc | Gli | microtubules | Sonic | shh | Indian | ihh | Desert | dhh

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

JK184

Based on 14 reference(s) in Google Scholar 10 10 14

Axon 2654

CAS [315703-52-7]

MF C19H18N4OS
MW 350.44

Purity: 100%
Soluble in DMSO and Ethanol

JK184

Description

Antagonist of Hedgehog (Hh) signaling (IC50 value of 30 nM for inhibition of Gli-dependent transcriptional activity) and a potent inhibitor of microtubule assembly that exhibits good antiproliferative activity both in vitro and in vivo. JK184 appears to act by inhibition of Adh7 (Kd value 210 nM in a assay for enzymatic oxidation of retinol).

KEYWORDS: JK184 | supplier | Hedgehog inhibitor | JK-184 | CAS [315703-52-7] | [466638-53-9] | Hedgehog | ADH | Antagonist | Hh | Smoothened | Smo | Patched | Ptch1 | Ptc | Gli | microtubules | Sonic | shh | Indian | ihh | Desert | dhh

J Lee et al. A small-molecule antagonist of the hedgehog signaling pathway. Chembiochem. 2007 Nov 5;8(16):1916-9.

T Cupido et al. The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling. Angew Chem Int Ed Engl. 2009;48(13):2321-4.

Hedgehog (Hh) signaling pathway antagonist with antiproliferative activity

Chemical name

N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine

Parent CAS No.

[315703-52-7]

产品资料