产品名称

Elafibranor - GFT505

产品货号

Axon 2727 CAS [824932-88-9] MF C22H24O4SMW 384.49 Purity: 98% Soluble in 0.1N NaOH(aq) and DMSO Description The dual PPARα/δ agonist Elafibrinor (GFT505) (EC50 values of 45 nM and 175 nM for PPARα and PPARδ, respectively) is a liver-targeted insulin-sensitizer that is a drug candidate for the treatment of type 2 diabetes, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NAS). In animals, its protective effects are mediated by both PPAR-α-dependent and -independent mechanisms. KEYWORDS: Elafibranor | supplier | PPAR α/δ agonist | GFT505 | GFT 505 | GFT-505 | CAS [824932-88-9] | CAS [923978-27-2] | Metabolism | PPAR | Agonist | Receptors | Insulin | Diabetes | NAFLD | NAS | Steatohepatitis | Peroxisome Proliferator-activated Receptor

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Elafibranor - GFT505

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2727

CAS [824932-88-9]

MF C22H24O4S
MW 384.49

Purity: 98%
Soluble in 0.1N NaOH(aq) and DMSO

Elafibranor

Description

The dual PPARα/δ agonist Elafibrinor (GFT505) (EC50 values of 45 nM and 175 nM for PPARα and PPARδ, respectively) is a liver-targeted insulin-sensitizer that is a drug candidate for the treatment of type 2 diabetes, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NAS). In animals, its protective effects are mediated by both PPAR-α-dependent and -independent mechanisms.

KEYWORDS: Elafibranor | supplier | PPAR α/δ agonist | GFT505 | GFT 505 | GFT-505 | CAS [824932-88-9] | CAS [923978-27-2] | Metabolism | PPAR | Agonist | Receptors | Insulin | Diabetes | NAFLD | NAS | Steatohepatitis | Peroxisome Proliferator-activated Receptor

B Cariou et al. Effects of the new dual PPAR α/δ agonist GFT505 on lipid and glucose homeostasis in abdominally obese patients with combined dyslipidemia or impaired glucose metabolism. Diabetes Care. 2011 Sep;34(9):2008-14.

B Cariou et al. Dual Peroxisome Proliferator–Activated Receptor α/δ Agonist GFT505 Improves Hepatic and Peripheral Insulin Sensitivity in Abdominally Obese Subjects. Diabetes Care. 2013 Oct; 36(10): 2923–2930.

B Staels et al. Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. Hepatology. 2013 Dec;58(6):1941-52.

Cell Signaling & Oncology Diabetes & Metabolism PPAR NR1C

Dual PPARα/δ agonist

Chemical name

(E)-2-(2,6-Dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxoprop-1-enyl)phenoxy)-2-methylpropanoic acid

Parent CAS No.

[824932-88-9]

产品资料