产品名称

PD 173074

产品货号

Axon 1673 CAS [219580-11-7] MF C28H41N7O3MW 523.67 Purity: 99% Soluble in DMSO and Ethanol Description Potent and selective FGFR inhibitor with IC50 to be 21.5 and 5 nM for FGRF1 and FGFR3 inhibition respectively References Certificates Categories Extra info OE Pardo et al. The Fibroblast Growth Factor Receptor Inhibitor PD173074 Blocks Small Cell Lung Cancer Growth In vitro and In vivo. Cancer Res. 2009, 69, 8645. M Miyake et al. 1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea (PD173074), a selective tyrosine kinase inhibitor of FGFR3 (...). J. Pharmacol. Exp. Ther. 2010, 332 795. L Zaragosi et al. Autocrine fibroblast growth factor 2 signaling is critical for self-renewal of human multipotent adipose-derived stem cells. Stem Cells 2006, 24 2412-2419. Certificate of Analysis Material Safety Data Sheet Angiogenesis Cell Signaling & Oncology Stem Cell RTK class V; EC 2.7.10.1 Stem Cell Differentiator FGFR Pfizer Licensed Products FGFR1 and FGFR3 inhibitor Chemical name 1-tert-butyl-3-(2-(4-(diethylamino)butylamino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea Source information Pfizer compound; Sold for research purposes under agreement from Pfizer Inc. Parent CAS No. [219580-11-7] Order Size Unit Price Stock 5 mg €75.00 In Stock

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现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

PD 173074

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1673

CAS [219580-11-7]

MF C28H41N7O3
MW 523.67

Purity: 99%
Soluble in DMSO and Ethanol

PD 173074

Description

Potent and selective FGFR inhibitor with IC50 to be 21.5 and 5 nM for FGRF1 and FGFR3 inhibition respectively

OE Pardo et al. The Fibroblast Growth Factor Receptor Inhibitor PD173074 Blocks Small Cell Lung Cancer Growth In vitro and In vivo. Cancer Res. 2009, 69, 8645.

M Miyake et al. 1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea (PD173074), a selective tyrosine kinase inhibitor of FGFR3 (...). J. Pharmacol. Exp. Ther. 2010, 332 795.

L Zaragosi et al. Autocrine fibroblast growth factor 2 signaling is critical for self-renewal of human multipotent adipose-derived stem cells. Stem Cells 2006, 24 2412-2419.

Angiogenesis Cell Signaling & Oncology Stem Cell RTK class V; EC 2.7.10.1 Stem Cell Differentiator FGFR Pfizer Licensed Products

FGFR1 and FGFR3 inhibitor

Chemical name

1-tert-butyl-3-(2-(4-(diethylamino)butylamino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea

Source information

Pfizer compound; Sold for research purposes under agreement from Pfizer Inc.

Parent CAS No.

[219580-11-7]

产品资料