| 产品名称 | GSK 2578215A |
| 产品货号 | Axon 2181 CAS [1285515-21-0] MF C24H18FN3O2MW 399.42 Purity: 99% Soluble in DMSO Description Potent and exceptionally highly selective Leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC50 values 10.9 and 8.9 nM for wild-type LRRK2 and LRRK2[G2019S] mutant, respectively.) GSK2578215A possesses good blood-brain barrier (BBB) permeability with a high ratio of brain to plasma distribution in mice. References Certificates Categories Extra info A.D. Reith et al. GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor. Bioorg. Med. Chem. Lett. 2012, 22, 5625-5629. M.E. Kavanagh et al. The development of CNS-active LRRK2 inhibitors using property-directed optimisation. Bioorg. Med. Chem. Lett. 2013, 23, 3690-3696. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology CNS Pain & Inflammation LRRK2 Ubiquitin EC 2.7.11.1 Potent and highly selective LRRK2 inhibitor Chemical name 2-(benzyloxy)-5-(2-fluoropyridin-4-yl)-N-(pyridin-3-yl)benzamide Parent CAS No. [1285515-21-0] Order Size Unit Price Stock 10 mg €125.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
GSK 2578215AAxon 2181 CAS [1285515-21-0] MF C24H18FN3O2
Description
Potent and exceptionally highly selective Leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC50 values 10.9 and 8.9 nM for wild-type LRRK2 and LRRK2[G2019S] mutant, respectively.) GSK2578215A possesses good blood-brain barrier (BBB) permeability with a high ratio of brain to plasma distribution in mice.
Potent and highly selective LRRK2 inhibitor
Chemical name2-(benzyloxy)-5-(2-fluoropyridin-4-yl)-N-(pyridin-3-yl)benzamide Parent CAS No.[1285515-21-0] |
| 产品资料 |
