产品名称

Brivanib alaninate - BMS 582664

产品货号

Axon 1864 CAS [649735-63-7] MF C22H24FN5O4MW 441.46 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Brivalib alaninate (BMS 582664) is the orally active prodrug of BMS 540215 (Axon 1850). Brivanib alaninate hydrolyzes in vivo quickly to BMS 540215, which is a potent and ATP-competitive VEGFR inhibitor with IC50 of 25, 380 and 10 nM for VEGFR2, -1 and -3 respectively; also showed good selectivity for FGFR-1, -2, and -3 with IC50 of 148, 125 and 68 nM References Certificates Categories Extra info ZW Cai et al. Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular (...). J. Med. Chem. 2008, 51(6), 1976-1980. H Huynh et al. Brivanib Alaninate, a Dual Inhibitor of Vascular Endothelial Growth Factor Receptor and Fibroblast Growth Factor Receptor Tyrosine Kinases, Induces Growth Inhibition in Mouse Models (...). Clin. Cancer Res. 2008, 14, 6146. Certificate of Analysis Material Safety Data Sheet Angiogenesis Cell Signaling & Oncology VEGFR RTK class IV; EC 2.7.10.1 Prodrug of BMS 540215; Inhibitor of VEGF Chemical name (S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-yl) 2-aminopropanoate Parent CAS No. [649735-63-7] Order Size Unit Price Stock 2 mg €105.00 In Stock

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Brivanib alaninate - BMS 582664

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 1864

CAS [649735-63-7]

MF C22H24FN5O4
MW 441.46

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

Brivanib alaninate

Description

Brivalib alaninate (BMS 582664) is the orally active prodrug of BMS 540215 (Axon 1850). Brivanib alaninate hydrolyzes in vivo quickly to BMS 540215, which is a potent and ATP-competitive VEGFR inhibitor with IC50 of 25, 380 and 10 nM for VEGFR2, -1 and -3 respectively; also showed good selectivity for FGFR-1, -2, and -3 with IC50 of 148, 125 and 68 nM

ZW Cai et al. Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular (...). J. Med. Chem. 2008, 51(6), 1976-1980.

H Huynh et al. Brivanib Alaninate, a Dual Inhibitor of Vascular Endothelial Growth Factor Receptor and Fibroblast Growth Factor Receptor Tyrosine Kinases, Induces Growth Inhibition in Mouse Models (...). Clin. Cancer Res. 2008, 14, 6146.

Angiogenesis Cell Signaling & Oncology VEGFR RTK class IV; EC 2.7.10.1

Prodrug of BMS 540215; Inhibitor of VEGF

Chemical name

(S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-yl) 2-aminopropanoate

Parent CAS No.

[649735-63-7]

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