| 产品名称 | Pelitinib - EKB 569 |
| 产品货号 | Axon 1665 CAS [257933-82-7 ] MF C24H23ClFN5O2MW 467.92 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description An irreversible inhibitor of EGFR tyrosine kinase with potential antineoplastic activity. Pelitinib irreversibly binds covalently to EGFR ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors References Certificates Categories Extra info M Nunes et al. Phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase B, and signal transducer and activator of transcription 3 are differently inhibited by an EGFR inhibitor, EKB-569, (...). Mol. Cancer Ther. 2004, 3,21. C Erlichman et al. Phase I study of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor, in patients with advanced solid tumors. J. Clin. Oncol. 2006, 24(15), 2252-2260. A Ocaña and E Amir. Irreversible pan-ErbB tyrosine kinase inhibitors and breast cancer: current status and future directions. Cancer Treat Rev. 2009, 5(8), 685-691. Certificate of Analysis Material Safety Data Sheet Angiogenesis Cell Signaling & Oncology EGFR JAK-STAT RTK class I; EC 2.7.10.1 EGFR tyrosine kinase inhibitor Chemical name (E)-N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide Parent CAS No. [257933-82-7 ] Order Size Unit Price Stock 5 mg €95.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
Pelitinib - EKB 569Axon 1665 CAS [257933-82-7 ] MF C24H23ClFN5O2
Description
An irreversible inhibitor of EGFR tyrosine kinase with potential antineoplastic activity. Pelitinib irreversibly binds covalently to EGFR ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors
EGFR tyrosine kinase inhibitor
Chemical name(E)-N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide Parent CAS No.[257933-82-7 ] |
| 产品资料 |
