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产品名称 R 55 - NSC 55712 | TPT 260 dihydrochloride |
产品货号 Axon 2303 CAS [2076-91-7] MF C8H14Cl2N4S3MW 333.32 Purity: 98% Soluble in water and DMSO Description Retromer stabilizing pharmacological chaperone (Kd value ~5 μM) that binds at the Vps29 and Vps35 interface, and reduces Aβ peptide accumulation (IC50 value ~12 µM) and the pathogenic pathway of APP; useful pharmacological tool for research on Alzheimer's disease. Thiophene derivative R55 was originally tested and proved active for its anticancer activity against Yoshida sarcoma. References Certificates Categories Extra info V.J. Mecozzi et al. Pharmacological chaperones stabilize retromer to limit APP processing. Nat Chem Biol. 2014 Jun;10(6):443-9. doi: 10.1038/nchembio.1508.   V.N. Gogte et al. Synthesis of potential anticancer agents. I. Synthesis of substituted thiophenes. Tetrahedron. 1967 May;23(5):2437-41. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS Retromer Retromer stabilizing pharmacological chaperone. Potential Alzheimer's therapeutic Chemical name thiophene-2,5-diylbis(methylene) dicarbamimidothioate dihydrochloride Parent CAS No. [769856-81-7] Order Size Unit Price Stock 10 mg €95.00 In Stock
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R 55 - NSC 55712 | TPT 260 dihydrochloride |

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2303

CAS [2076-91-7]

MF C8H14Cl2N4S3
MW 333.32

  • Purity: 98%
  • Soluble in water and DMSO

R 55

Description

Retromer stabilizing pharmacological chaperone (Kd value ~5 μM) that binds at the Vps29 and Vps35 interface, and reduces Aβ peptide accumulation (IC50 value ~12 µM) and the pathogenic pathway of APP; useful pharmacological tool for research on Alzheimer's disease.
Thiophene derivative R55 was originally tested and proved active for its anticancer activity against Yoshida sarcoma.
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