产品名称

Deltarasin trihydrochloride

产品货号

Axon 2284 CAS [1440898-82-7] MF C40H37N5O.3HClMW 713.14 Purity: 99% Optical purity: Optically pure Soluble in water and DMSO Description Small molecule inhibitor of the KRAS–PDEδ interaction that impairs oncogenic KRAS signalling by altering its localization to endomembranes (in cell Kd value 41 nM for deltarasin binding to PDEδ). Deltarasin suppresses in vitro and in vivo MAPK signaling and proliferation of human pancreatic ductal adenocarcinoma (PDAC) cells that are dependent on oncogenic KRAS. References Certificates Categories Extra info G. Zimmermann et al.Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling. Nature 2013, 497, 638-642. B. Frett et al. Targeting the K-Ras/PDEδ Protein–Protein Interaction: The Solution for Ras-Driven Cancers or Just Another Therapeutic Mirage? ChemMedChem 2013, 8, 1620-1622. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology MAPK PDE Inhibitor of the prenyl binding protein PDEδ and the KRAS–PDEδ interaction. Chemical name (S)-1-benzyl-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethylphenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole trihydrochloride Parent CAS No. [1440898-61-2] Order Size Unit Price Stock 5 mg €115.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Deltarasin trihydrochloride

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2284

CAS [1440898-82-7]

MF C40H37N5O.3HCl
MW 713.14

Purity: 99%
Optical purity: Optically pure
Soluble in water and DMSO

Deltarasin trihydrochloride

Description

Small molecule inhibitor of the KRAS–PDEδ interaction that impairs oncogenic KRAS signalling by altering its localization to endomembranes (in cell Kd value 41 nM for deltarasin binding to PDEδ). Deltarasin suppresses in vitro and in vivo MAPK signaling and proliferation of human pancreatic ductal adenocarcinoma (PDAC) cells that are dependent on oncogenic KRAS.

G. Zimmermann et al.Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling. Nature 2013, 497, 638-642.

B. Frett et al. Targeting the K-Ras/PDEδ Protein–Protein Interaction: The Solution for Ras-Driven Cancers or Just Another Therapeutic Mirage? ChemMedChem 2013, 8, 1620-1622.

Inhibitor of the prenyl binding protein PDEδ and the KRAS–PDEδ interaction.

Chemical name

(S)-1-benzyl-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethylphenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole trihydrochloride

Parent CAS No.

[1440898-61-2]

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