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产品名称 NEO 212 - TMZ-POH
产品货号 Axon 2327 CAS [1361198-79-9] MF C17H20N6O4MW 372.38 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Novel DNA alkylating agent exhibiting superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo (IC50 values 5-50 µM for cytotoxicity on glioma cell lines). NEO 212 causes DNA damage and cell death much more efficiently than TMZ, because linkage with POH increased its biological half-life and thus provided greater opportunity for placement of cytotoxic DNA lesions.NEO212 is a conjugate of temozolomide (TMZ, Axon 2326) with the natural product perillyl alcohol (POH) and circumvents TMZ-resistance in multiple cancer cell lines and gliomas. References Certificates Categories Extra info T.C. Chen et al. A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. Mol. Cancer Ther. 2014, 13, 1181-1193.   H.Y. Cho et al. NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas. Mol. Cancer Ther. 2014, 13, 2004-2017. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology DNA-damage Response DNA DNA alkylating agent; chemotherapeutic Chemical name (S)-(4-(Prop-1-en-2-yl)cyclohex-1-enyl)methyl 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonylcarbamate Parent CAS No. [1361198-79-9] Order Size Unit Price Stock 5 mg €110.00 In Stock
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NEO 212 - TMZ-POH

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2327

CAS [1361198-79-9]

MF C17H20N6O4
MW 372.38

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO

NEO 212

Description

Novel DNA alkylating agent exhibiting superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo (IC50 values 5-50 µM for cytotoxicity on glioma cell lines). NEO 212 causes DNA damage and cell death much more efficiently than TMZ, because linkage with POH increased its biological half-life and thus provided greater opportunity for placement of cytotoxic DNA lesions.
NEO212 is a conjugate of temozolomide (TMZ, Axon 2326) with the natural product perillyl alcohol (POH) and circumvents TMZ-resistance in multiple cancer cell lines and gliomas.
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