产品名称

Y 29794 tosylate

产品货号

Axon 2911 CAS [143984-17-2] MF C23H34N2OS2.C7H8O3SMW 590.86 Purity: 99% Soluble in DMSO Description Y 29794 tosylate is an orally active, potent and specific prolyl endopeptidase (PPCE) inhibitor that is easily penetrable into the brain. Y-29794 tosylate selectively and competitively inhibited rat brain PPCE in a reversible manner with a Ki value of 0.95 nM. Moreover, Y 29794 tosylate exhibited potent inhibitory activity with an IC50 value of 3.0 nM for both brain crude extract and partially purified enzyme fraction. KEYWORDS: Y 29794 tosylate | supplier | PPCE inhibitor | Y29794 tosylate | Y-29794 tosylate | CAS [143984-17-2] | [129184-48-1] | [146794-84-5] | Non Selective (Serine Peptide Bonds) | Prolyl endopeptidase | Inhibitor | Enzymes | Alzheimer's disease

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Y 29794 tosylate

Based on 3 reference(s) in Google Scholar 8 10 3

Axon 2911

CAS [143984-17-2]

MF C23H34N2OS2.C7H8O3S
MW 590.86

Purity: 99%
Soluble in DMSO

Y 29794 tosylate

Description

Y 29794 tosylate is an orally active, potent and specific prolyl endopeptidase (PPCE) inhibitor that is easily penetrable into the brain. Y-29794 tosylate selectively and competitively inhibited rat brain PPCE in a reversible manner with a Ki value of 0.95 nM. Moreover, Y 29794 tosylate exhibited potent inhibitory activity with an IC50 value of 3.0 nM for both brain crude extract and partially purified enzyme fraction.

T Nakajima et al. Y-29794 - a non-peptide prolyl endopeptidase inhibitor that can penetrate into the brain. Neurosci Lett. 1992 Jul 20;141(2):156-60.

Orally active, brain penetrant, potent and specific prolyl endopeptidase (PPCE) inhibitor

Chemical name

(2-(8-(Dimethylamino)octylthio)-6-isopropylpyridin-3-yl)(thiophen-2-yl)methanone tosylate

Parent CAS No.

[129184-48-1]

产品资料