产品名称

YMU1

产品货号

Axon 2675 CAS [902589-96-2] MF C17H22N4O4SMW 378.45 Purity: 99% Soluble in DMSO Description Selective human thymidylate kinase (hTMPK; IC50 value 1.65 µM) inhibitor that lacks inhibitory effect on the activity of purified thymidine kinase 1 (TK1). YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site. Blocking hTMPK by YMU1 attenuates the ATP binding-induced closed conformation that is required for phosphorylation of dTMP, and sensitizes cancer cells for low-dose doxorubicin chemotherapy. Keywords: YMU1 | supplier | TMPK inhibtor | YMU-1 | YMU 1 | CAS [902589-96-2] | Thymidylate pathway | hTMPK | Phosphotransferase | dTTP | dTMP | doxorubicin | tuberculosis | cancer

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

YMU1

Based on 1 reference(s) in Google Scholar 10 10 1

Axon 2675

CAS [902589-96-2]

MF C17H22N4O4S
MW 378.45

Purity: 99%
Soluble in DMSO

YMU1

Description

Selective human thymidylate kinase (hTMPK; IC50 value 1.65 µM) inhibitor that lacks inhibitory effect on the activity of purified thymidine kinase 1 (TK1). YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site. Blocking hTMPK by YMU1 attenuates the ATP binding-induced closed conformation that is required for phosphorylation of dTMP, and sensitizes cancer cells for low-dose doxorubicin chemotherapy.

YH Chen et al. Chemical Inhibition of Human Thymidylate Kinase and Structural Insights into the Phosphate Binding Loop and Ligand-Induced Degradation. J Med Chem. 2016 Nov 10;59(21):9906-9918.

Selective inhibitor of human thymidylate kinase (hTMPK)

Chemical name

ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate

Parent CAS No.

[902589-96-2]

产品资料