产品名称

Nolatrexed dihydrochloride - AG 337 | Thymitaq

产品货号

Axon 2853 CAS [152946-68-4] MF C14H12N4OS.2HClMW 357.26 Purity: 98% Soluble in DMSO and water Description Nolatrexed dihydrochloride is a water soluble, lipophilic inhibitor of thymidylate synthase (Ki value of 11 nM). Nolatrexed dihydrochloride displayed non-competitive inhibition kinetics and was shown to inhibit cell growth in a panel of cell lines of murine and human origin (IC50 values between 0.39 and 6.6 µM). KEYWORDS: Nolatrexed dihydrochloride | supplier | Thymidylate synthase inhibitor | AG 337 | Thymitaq | AG337 | AG-337 | CAS [152946-68-4] | [147149-76-6] | Deoxyuridine monophosphate (dUMP) | TYMS | Inhibitor | Enzymes

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产品规格

产品品牌

axonmedchem

产品概述

产品详情

Nolatrexed dihydrochloride - AG 337 | Thymitaq

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2853

CAS [152946-68-4]

MF C14H12N4OS.2HCl
MW 357.26

Purity: 98%
Soluble in DMSO and water

Nolatrexed dihydrochloride

Description

Nolatrexed dihydrochloride is a water soluble, lipophilic inhibitor of thymidylate synthase (Ki value of 11 nM). Nolatrexed dihydrochloride displayed non-competitive inhibition kinetics and was shown to inhibit cell growth in a panel of cell lines of murine and human origin (IC50 values between 0.39 and 6.6 µM).

S Webber et al. AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies. Cancer Chemother Pharmacol. 1996;37(6):509-17.

Water soluble inhibitor of thymidylate synthase

Chemical name

2-Amino-6-methyl-5-(pyridin-4-ylthio)quinazolin-4(3H)-one dihydrochloride

Parent CAS No.

[147149-76-6]

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