产品名称

ZL006

产品货号

Axon 2878 CAS [1181226-02-7] MF C14H11Cl2NO4MW 328.15 Purity: 99% Soluble in DMSO Description ZL006 blocked the ischemia-induced nNOS–PSD-95 association selectively, had potent neuroprotective activity in vitro and ameliorated focal cerebral ischemic damage in mice and rats subjected to middle cerebral artery occlusion (MCAO) and reperfusion. Moreover, it readily crossed the blood-brain barrier, did not inhibit NMDAR function, catalytic activity of nNOS or spatial memory, and had no effect on aggressive behaviors. KEYWORDS: ZL006 | supplier | nNOS-PSD-95 inhibitor | ZL 006 | ZL-006 | CAS [1181226-02-7] | Arginine, L- | NOS | Inhibitor | Enzymes | Stroke | Cerebral ischemia | Nitric oxide synthase

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

ZL006

Based on 23 reference(s) in Google Scholar 8 10 23

Axon 2878

CAS [1181226-02-7]

MF C14H11Cl2NO4
MW 328.15

Purity: 99%
Soluble in DMSO

ZL006

Description

ZL006 blocked the ischemia-induced nNOS–PSD-95 association selectively, had potent neuroprotective activity in vitro and ameliorated focal cerebral ischemic damage in mice and rats subjected to middle cerebral artery occlusion (MCAO) and reperfusion. Moreover, it readily crossed the blood-brain barrier, did not inhibit NMDAR function, catalytic activity of nNOS or spatial memory, and had no effect on aggressive behaviors.

L Zhou et al. Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95. Nat Med. 2010 Dec;16(12):1439-43.

Selective inhibitor of the nNOS-PSD-95 interaction

Chemical name

4-(3,5-Dichloro-2-hydroxybenzylamino)-2-hydroxybenzoic acid

Parent CAS No.

[1181226-02-7]

产品资料