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产品名称 ONO 5334
产品货号 Axon 2156 CAS [868273-90-9] MF C21H34N4O4SMW 438.58 Purity: 98% Optical purity: Optically pure Soluble in DMSO Description Potent and orally available inhibitor of cathepsin K (Ki values of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat respectively). ONO 5334 dose depedently suppresses human osteoclast-mediated bone resorption in vitro, and reduced PTHrP-induced increase in plasma calcium with significant effect (86% reduction) after oral administration in TPTX pretreated rats. References Certificates Categories Extra info R. Eastell et al. Effect of ONO-5334 on Bone Mineral Density and Biochemical Markers of Bone Turnover in Postmenopausal Osteoporosis: 2-Year Results From the OCEAN Study. J. Bone Miner Res. 2014, 29, 458-466.    Y. Ochi et al. Effects of ONO-5334, a novel orally-active inhibitor of cathepsin K, on bone metabolism. Bone. 2011, 49, 1351-1356.  Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Miscellaneous Cathepsin-K EC 3.4.22.8 Potent and orally available inhibitor of cathepsin K Chemical name N-((R)-3-((Z)-2-((R)-3,4-dimethylthiazolidin-2-ylidene)hydrazinyl)-2,3-dioxo-1-(tetrahydro-2H-pyran-4-yl)propyl)cycloheptanecarboxamide Parent CAS No. [868273-90-9] Order Size Unit Price Stock 2 mg €110.00 In Stock
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ONO 5334

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2156

CAS [868273-90-9]

MF C21H34N4O4S
MW 438.58

  • Purity: 98%
  • Optical purity: Optically pure
  • Soluble in DMSO

ONO 5334

Description

Potent and orally available inhibitor of cathepsin K (Ki values of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat respectively). ONO 5334 dose depedently suppresses human osteoclast-mediated bone resorption in vitro, and reduced PTHrP-induced increase in plasma calcium with significant effect (86% reduction) after oral administration in TPTX pretreated rats.
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