| 产品名称 | CX 6258 hydrochloride |
| 产品货号 | Axon 2305 CAS [1353859-00-3] MF C26H24ClN3O3.HClMW 498.40 Purity: 99% Soluble in DMSO Description Potent, selective, and orally efficacious pan-Pim kinases inhibitor (IC50 values 5 nM, 25 nM, and 16 nM for Pim-1, Pim-2, and Pim-3 respectively) with 5-40 fold selectivity over Flt-3 (IC50 values 0.134 μM).CX 6258 exhibited dose dependent efficacy in a mouse MV-4-11 xenograft study, with a 50 mg/kg dose producing 45% tumor growth inhibition (TGI) and a 100 mg/kg dose producing 75% TGI, and was well tolerated throughout the study. References Certificates Categories Extra info M. Haddach et al. Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor. ACS Med. Chem. Lett. 2011, 3, 135-139. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Epigenetics Immunology JAK-STAT EC 2.7.11.1 PIM Pim kinase inhibitor Chemical name (E)-5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one hydrochloride Parent CAS No. [1202916-90-2] Order Size Unit Price Stock 5 mg €99.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
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| 产品详情 |
CX 6258 hydrochlorideAxon 2305 CAS [1353859-00-3] MF C26H24ClN3O3.HCl
Description
Potent, selective, and orally efficacious pan-Pim kinases inhibitor (IC50 values 5 nM, 25 nM, and 16 nM for Pim-1, Pim-2, and Pim-3 respectively) with 5-40 fold selectivity over Flt-3 (IC50 values 0.134 μM).CX 6258 exhibited dose dependent efficacy in a mouse MV-4-11 xenograft study, with a 50 mg/kg dose producing 45% tumor growth inhibition (TGI) and a 100 mg/kg dose producing 75% TGI, and was well tolerated throughout the study.
Pim kinase inhibitor
Chemical name(E)-5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one hydrochloride Parent CAS No.[1202916-90-2] |
| 产品资料 |
